4-Amino-2-chloro-6,7-dimethoxyquinazoline

CAS: 23680-84-4

Ref. 3D-FA156914

Product Information

• Name: 4-Amino-2-chloro-6,7-dimethoxyquinazoline
• Synonyms: Alfuzosin hydrochloride impurity B2-Chloro-6,7-dimethoxy-4-quinazolinamine
• Brand: Biosynth
• Description: 4-Amino-2-chloro-6,7-dimethoxyquinazoline (4ACDMQ) is a synthetic compound that has been used as a chemical intermediate. The chemical structure of 4ACDMQ is similar to that of the natural amino acid tryptophan. It is synthesized by reacting phosphorus pentachloride with 2,6,7-trimethoxyquinazoline in the presence of hydroxide solution and hexamethylphosphoramide. 4ACDMQ has been shown to be an inhibitor of ubiquitin proteasome system and has been used in functional studies on this system. The reaction yield for 4ACDMQ can be increased by using sodium hydroxide solution or n-dimethyl formamide as a solvent. Functional assays have shown binding properties for 4ACDMQ to proteins such as ubiquitin and proteasome subunits.

Chemical properties

• Molecular weight: 239.66 g/mol
• Formula: C₁₀H₁₀ClN₃O₂
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C10H10ClN3O2/c1-15-7-3-5-6(4-8(7)16-2)13-10(11)14-9(5)12/h3-4H,1-2H3,(H2,12,13,14)
• InChI key: InChIKey=HWIIAAVGRHKSOJ-UHFFFAOYSA-N
• SMILES: COc1cc2nc(Cl)nc(N)c2cc1OC