6-Amino-2-methylthio-4(3H)pyrimidinone

CAS: 1074-41-5

Ref. 3D-FA17468

Product Information

• Name: 6-Amino-2-methylthio-4(3H)pyrimidinone
• Synonyms: 2-(Methylthio)-4-amino-6-hydroxypyrimidine4-Amino-6-hydroxy-2-(methylthio)pyrimidine6-Amino-2-methylsulfanyl-3,4-dihydropyrimidin- 4-one, 4(3H)-pyrimidinone, 6-amino-2-(methylthio)-, 4-Pyrimidinol, 6-Amino-2-(Methylthio)-, 6-Amino-2-(methylsulfanyl)pyrimidin-4(3H)-one, 6-Amino-2-(methylsulfanyl)pyrimidin-4-ol, 6-amino-2-(methylsulfanyl)pyrimidin-4(1H)-one

Description

6-Amino-2-methylthio-4(3H)pyrimidinone is a potential antitumor drug with a radical mechanism of action. It inhibits the activity of the NS5B polymerase, an enzyme in the virus's RNA replication complex. The drug has been shown to inhibit proliferation of cancer cells in vitro and to have antiviral effects against a number of viruses, including influenza A and B. 6-Amino-2-methylthio-4(3H)pyrimidinone inhibits tyrosine kinases and also inhibits erythrocyte progenitors from differentiating into megakaryocytes. This drug is not metabolized by cytochrome P450 enzymes and does not bind to plasma proteins.

• Brand: Biosynth

Chemical properties

• Molecular weight: 157.19 g/mol
• Formula: C₅H₇N₃OS
• Purity: Min. 95%
• Color/Form: White Powder
• InChI: InChI=1S/C5H7N3OS/c1-10-5-7-3(6)2-4(9)8-5/h2H,1H3,(H3,6,7,8,9)
• InChI key: InChIKey=PXYQQKWEFDEUIX-UHFFFAOYSA-N
• SMILES: CSc1nc(N)cc(=O)[nH]1