Azatadine dimaleate

CAS: 3978-86-7

Ref. 3D-FA18063

Product Information

• Name: Azatadine dimaleate
• Synonyms: 6,11-Dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridineAzatadine Dimaleate, 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine dimaleate, 11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine di[(2Z)-but-2-enedioate], 5-(4′-N-Methylpiperidylidene)-4-azo-10:11-dihydrodibenzocycloheptene dimaleate, 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-, (2Z)-2-butenedioate (1:2), 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-, (Z)-2-butenedioate (1:2), 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 6,11-dihydro-11-(1-methyl-4-piperidylidene)-, maleate (1:2), Atoramin, Azatadine Maleate, Bonamid, Idulian, Optimine, Sch 10649, Trinalin, Zadine

Description

Azatadine is an antihistamine that has been shown to be clinically relevant for the treatment of allergic symptoms. Azatadine has been shown to bind to voltage-dependent calcium channels and inhibit their opening, preventing the release of neurotransmitters such as acetylcholine. Azatadine also blocks leukotriene receptors and therefore its activity is antagonistic with fatty acid synthase inhibitors and other pharmacological agents.
Azatadine dimaleate (AZA) is a prodrug that is metabolized in vivo by esterases into the active form, azatadine. AZA inhibits histamine release from mast cells in vitro and in vivo models. This drug also has anti-inflammatory properties that may be due to its inhibition of prostaglandin synthesis.

• Brand: Biosynth

Chemical properties

• Molecular weight: 522.55 g/mol
• Formula: C₂₀H₂₂N₂·2C₄H₄O₄
• Purity: Min. 95%
• InChI: InChI=1S/C20H22N2.2C4H4O4/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19;2*5-3(6)1-2-4(7)8/h2-7,12H,8-11,13-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
• InChI key: InChIKey=SGHXFFAHXTZRQM-SPIKMXEPSA-N
• SMILES: CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1.O=C(O)/C=C\C(=O)O.O=C(O)/C=C\C(=O)O