5-Aminouracil

CAS: 932-52-5

Ref. 3D-FA32347

Product Information

• Name: 5-Aminouracil
• Synonyms: 2,4(1H,3H)-Pyrimidinedione, 5-amino-, 2,4-Dihydroxy-5-aminopyrimidine, 5-Amino uracil, 5-Amino-2,4(1H,3H)-pyrimidinedione, 5-Amino-2,4-dihydroxypyrimidine, 5-Amino-2,4-pyrimidinediol, 5-aminopyrimidine-2,4(1H,3H)-dione, Ai3-50678, Nsc 22474, Uracil, 5-amino-

Description

5-Aminouracil is a pyrimidine nucleoside that is used in the treatment of cancer, psoriasis and other autoimmune disorders. 5-Aminouracil is a prodrug that undergoes intracellular transformation to become an inhibitor of DNA synthesis. It promotes apoptosis by inhibiting the production of RNA and protein synthesis, leading to cell death. 5-Aminouracil has been shown to be effective against malignant cells in tissue culture as well as various types of cancer cells. A study using hydrogen bonding interactions showed that 5-aminouracil binds to the ribosomal protein L10 and inhibits its function in the polymerase chain reaction (PCR). Molecular docking studies have also shown that this drug can bind with redox potentials in both the active site and ligand binding site of human topoisomerase II alpha, which may lead to inhibition of enzyme activity or cell death.

• Brand: Biosynth

Chemical properties

• Molecular weight: 127.1 g/mol
• Formula: C₄H₅N₃O₂
• Purity: Min. 95%
• Color/Form: White Powder
• InChI: InChI=1S/C4H5N3O2/c5-2-1-6-4(9)7-3(2)8/h1H,5H2,(H2,6,7,8,9)
• InChI key: InChIKey=BISHACNKZIBDFM-UHFFFAOYSA-N
• SMILES: Nc1c[nH]c(=O)[nH]c1=O