N-Acetyl-L-tryptophan

CAS: 1218-34-4

Ref. 3D-FA37435

Product Information

• Name: N-Acetyl-L-tryptophan
• Synonyms: (2S)-2-Acetamido-3-(1H-indol-3-yl)propanoic acid, (S)-N-Acetyltryptophan, <span class="text-smallcaps">L</span>-N-Acetyltryptophan, <span class="text-smallcaps">L</span>-Tryptophan, N-acetyl-, Ac-L-Trp-OH, Acetyl-<span class="text-smallcaps">L</span>-tryptophan, Acetyltryptophan, N-Acetyl-<span class="text-smallcaps">L</span>-tryptophan, N-Acetyl-L-Tryptophan, N-acetyltryptophan, N-α-Acetyl-L-Tryptophan, NSC 90726, Tryptophan, N-acetyl-, <span class="text-smallcaps">L</span>-
• CAS: 1218-34-4

Description

N-Acetyl-L-tryptophan is a neuroprotective agent that binds to the group p2 receptor for neurokinin-1 (NK-1) and inhibits the apoptosis pathway. It is used in the treatment of Parkinson's disease, Alzheimer's disease, and Huntington's disease. N-Acetyl-L-tryptophan has been shown to inhibit inflammatory lesions in rats with experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. This drug also interacts with toll-like receptor 4 (TLR4), which activates downstream signaling cascades involving NFκB, MAP kinase, and JAK/STAT pathways. The molecular docking analysis revealed that N-acetyl tryptophan binds to specific sites on TLR4 and prevents its activation by preventing binding of LPS.

• Brand: Biosynth

Chemical properties

• Molecular weight: 246.26 g/mol
• Formula: C₁₃H₁₄N₂O₃
• Purity: Min. 95%
• Color/Form: Powder