C.I.Azoic Coupling Component 10

CAS: 92-78-4

Ref. 3D-FA41321

Product Information

• Name: C.I.Azoic Coupling Component 10
• Synonyms: 2-Hydroxy-3-Naphthoyl-p-Chloraniline, 2-Naphthalenecarboxamide, N-(4-chlorophenyl)-3-hydroxy-, 2-Naphthanilide, 4′-chloro-3-hydroxy-, 3-Hydroxy-4′-chloro-2-naphthanilide, 4′-Chloro-3-hydroxy-2-naphthanilide, Acna Naphthol PC, Amanil Naphthol AS-E, Amarthol AS-E, Anarthol AS-E, Azoic Coupling Component 10, Cibanaphthol RC, Conazoic AO, Daito Grounder E, Dycosthol AS-E, Hiltonaphthol AS-E, Kako Grounder E, Kiwa Grounder E, N-(4-Chlorophenyl)-3-hydroxy-2-naphthalenecarboxamide, N-(4-chlorophenyl)-3-hydroxynaphthalene-2-carboxamide, NSC 50684, Naftol AS-E, Naphtanilide E, Naphtazol E, Naphthol ACNA PC, Naphtoelan E, Naphtol AS-E Supra, Napthol ASE, Red RC Base, Sanatol E, Tulathol AS-E

Description

C.I.Azoic Coupling Component 10 is a molecule that has anticancer activity in the PC3 cancer cell line and the MDA-MB-231 breast cancer cell line. It is an inhibitor of the transcription factor, response element binding protein (REB). The molecule binds to DNA in a manner similar to that of platinum drugs and inhibits the synthesis of RNA by inhibiting RNA polymerase II. C.I.Azoic Coupling Component 10 also exhibits cytotoxic effects on leukemia cells, such as mcf-7 cells, which are resistant to chemotherapeutic agents.
The molecule is activated by hydroxyl groups and carbonyl groups in cancer tissues, which may be due to its ability to bind with factor receptors on tumor cells and inhibit their growth.

• Brand: Biosynth

Chemical properties

• Molecular weight: 297.74 g/mol
• Formula: C₁₇H₁₂ClNO₂
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C17H12ClNO2/c18-13-5-7-14(8-6-13)19-17(21)15-9-11-3-1-2-4-12(11)10-16(15)20/h1-10,20H,(H,19,21)
• InChI key: InChIKey=OHAXNCGNVGGWSO-UHFFFAOYSA-N
• SMILES: O=C(Nc1ccc(Cl)cc1)c1cc2ccccc2cc1O