Product Information
- (3-Chloro-4-cyanophenyl)amine
- 2-Chloro-4-aminobenzonitrile
- 3-Chloro-4-cyanoaniline
- Benzonitrile, 4-Amino-2-Chloro-
4-Amino-2-chlorobenzonitrile (4ACB) is a copper salt that can be used in antimalarial therapy. It has been shown to have strong antiplasmodial activity against the parasite Plasmodium falciparum and other species of the genus Plasmodium. 4ACB is synthesized by nitro group reduction and ammonolysis, followed by an addition reaction with chloroformate. 4ACB binds to the enzyme ferredoxin reductase and inhibits electron transfer, which leads to inhibition of ATP production and cell death. The molecular modelling study showed that 4ACB is a reactive molecule with high affinity constants for copper ion.
Chemical properties
Technical inquiry about: 3D-FA46636 4-Amino-2-chlorobenzonitrile
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