L-Aspartic acid b-benzyl ester

CAS: 2177-63-1

Ref. 3D-FA47538

Product Information

• Name: L-Aspartic acid b-benzyl ester
• Synonyms: L-Asp(OBzl)-OH, (2S)-2-Amino-4-(benzyloxy)-4-oxobutanoic acid, (2S)-2-Amino-4-oxo-4-phenylmethoxybutanoic acid, (2S)-2-amino-3-benzyloxy-3-oxo-propanoic acid, (2S)-2-amino-4-(benzyloxy)-4-oxobutanoic acid (non-preferred name), (3S)-3-ammonio-4-(benzyloxy)-4-oxobutanoate, 2-Amino-4-(Benzyloxy)-4-Oxobutanoic Acid (Non-Preferred Name), 3-Amino-4-(Benzyloxy)-4-Oxobutanoic Acid (Non-Preferred Name), 4-(Phenylmethyl) hydrogen <span class="text-smallcaps">L</span>-aspartate, 4-Benzyl <span class="text-smallcaps">L</span>-aspartate, <span class="text-smallcaps">L</span>-Aspartic acid 4-O-benzyl ester, <span class="text-smallcaps">L</span>-Aspartic acid 4-benzyl ester, <span class="text-smallcaps">L</span>-Aspartic acid β-benzyl ester, <span class="text-smallcaps">L</span>-Aspartic acid, 4-(phenylmethyl) ester, Aspartic acid β-benzyl ester, Aspartic acid, 4-benzyl ester, <span class="text-smallcaps">L</span>-, Benzyl aspartate, H-Asp(OBzl)-OH, H-Asp-OBzl, L-Aspartic acid benzyl ester, NSC 524167, β-Benzyl <span class="text-smallcaps">L</span>-aspartate, β-Benzyl aspartate

Description

L-Aspartic acid b-benzyl ester (L-ABE) is a cytostatic drug that is biodegradable and can be used in a variety of animal species. It has been shown to inhibit the growth of cancer cells in vitro and in vivo, as well as micelles. L-ABE inhibits the action of dehydroascorbic acid reductase, an enzyme that reduces dehydroascorbic acid to ascorbic acid. This inhibition leads to an increase in the concentration of dehydroascorbic acid, which may cause cell death by damaging DNA. L-ABE also has been shown to inhibit P-glycoprotein (Pgp), leading to increased accumulation of anticancer drugs such as doxorubicin, which can lead to cell death.

• Brand: Biosynth

Chemical properties

• Molecular weight: 223.23 g/mol
• Formula: C₁₁H₁₃NO₄
• Purity: Min. 95%
• Color/Form: White Powder