5-Aminopyridine-3-carboxylic acid

CAS: 24242-19-1

Ref. 3D-FA66664

Product Information

• Name: 5-Aminopyridine-3-carboxylic acid
• Synonyms: 5-Aminonicotinic acid, 3-Amino-5-pyridinecarboxylic acid, 5-Aminopyridine-3-Carboxylic Acid, 5-Aminopyridine-3-Carboxylate

Description

5-Aminopyridine-3-carboxylic acid (5APC) is a structural analog of nicotinic acid that has been shown to have anti-inflammatory effects. 5APC inhibits the production of inflammatory cytokines, such as IL-10 and IL-17, by inhibiting the activation of NFκB and MAPK pathways. This drug also has significant inhibitory activities against dextran sulfate sodium (DSS)-induced acute colitis in experimental models. 5APC is thought to act by interrupting the assembly of p38 mitogen activated protein kinase (MAPK) and nuclear factor kappa B (NFκB) signaling complexes.

5APC has been shown to reduce symptoms in patients with bowel disease, such as ulcerative colitis or Crohn's disease, who are unresponsive to other treatments. These drugs are not currently used for this purpose because they have not been approved by regulatory authorities.

• Brand: Biosynth

Chemical properties

• Molecular weight: 138.12 g/mol
• Formula: C₆H₆N₂O₂
• Purity: Min. 95%
• InChI: InChI=1S/C6H6N2O2/c7-5-1-4(6(9)10)2-8-3-5/h1-3H,7H2,(H,9,10)
• InChI key: InChIKey=BYIORJAACCWFPU-UHFFFAOYSA-N
• SMILES: Nc1cncc(C(=O)O)c1