2-Acetyl-3-phenylacrylic acid ethyl ester

CAS: 620-80-4

Ref. 3D-FA74680

Product Information

• Name: 2-Acetyl-3-phenylacrylic acid ethyl ester
• Synonyms: 3-Oxo-2-(phenylmethylene)butanoic acid ethyl ester, Butanoic Acid, 3-Oxo-2-(Phenylmethylene)-, Ethyl Ester, Cinnamic acid, α-acetyl-, ethyl ester, Ethyl 2-(acetyl)-3-phenyl-2-propenoate, Ethyl 2-benzylideneacetoacetate, Ethyl 3-oxo-2-(phenylmethylene)butanoate, Ethyl benzylideneacetoacetate, Ethyl α-acetylcinnamate, NSC 68527, ethyl (2Z)-3-oxo-2-(phenylmethylidene)butanoate

Description

2-Acetyl-3-phenylacrylic acid ethyl ester (APACHE) is a novel synthetic compound that has been shown to have potent antioxidant, antiangiogenic and radical scavenging activities in vivo. APACHE has been shown to inhibit tumor growth and angiogenesis in vitro. It also has potent antagonist activity against the platelet aggregation of human platelets and has been shown to have a cardio-protective effect in vivo. APACHE inhibits cell growth by reacting with acceptors like cysteine and glutathione, which are important for cell survival. Reaction time was found to be an important factor for the potency of APACHE as it can react with other molecules present in cells during the reaction time.
APACHE is synthesized from 2-acetylphenol via the chemical reaction of phenyllithium followed by acetylation with acetic anhydride, which is a postsynthetic modification. APACHE

• Brand: Biosynth

Chemical properties

• Molecular weight: 218.25 g/mol
• Formula: C₁₃H₁₄O₃
• Purity: Min. 95%
• Color/Form: Powder