Alanyl-phenylalanyl-lysine fluoromethane

CAS: 107573-17-1

Ref. 3D-FA85603

Product Information

• Name: Alanyl-phenylalanyl-lysine fluoromethane
• Synonyms: Ala-phe-lys-CH2F, L-alanyl-L-phenylalanyl-L-lysine - fluoromethane (1:1)

Description

Alanyl-phenylalanyl-lysine fluoromethane is a competitive inhibitor of the enzyme kallikrein. It binds to the active site of kallikrein and competes with the natural substrate peptidyl-piperidinium for binding, thereby inhibiting the activity of the enzyme. Alanyl-phenylalanyl-lysine fluoromethane has been shown to inhibit coagulation by blocking the activation of prothrombin and thrombin by kallikrein. This inhibition can be reversed by adding an anticoagulant such as heparin or hirudin. The biochemical assay used to measure this drug's effect on coagulation requires analysis using fluoroalkyl reagents, which are not suitable for use in human subjects.

• Brand: Biosynth

Chemical properties

• Molecular weight: 398.47 g/mol
• Formula: C₁₉H₃₁FN₄O₄
• Purity: Min. 95%
• InChI: InChI=1S/C18H28N4O4.CH3F/c1-12(20)16(23)22-15(11-13-7-3-2-4-8-13)17(24)21-14(18(25)26)9-5-6-10-19;1-2/h2-4,7-8,12,14-15H,5-6,9-11,19-20H2,1H3,(H,21,24)(H,22,23)(H,25,26);1H3/t12-,14-,15-;/m0./s1
• InChI key: InChIKey=DEXOLHUUTGWNNJ-XJPBFQKESA-N
• SMILES: CF.C[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)O