Product Information
- 1,5-Dimethyl 2-pentenedioate
- 2-Pentenedioic acid, 1,5-dimethyl ester
- 2-Pentenedioic acid, dimethyl ester
- Dimethyl 2-pentene-1,5-dioate
- Dimethyl 2-pentenedioate
- Dimethyl Pent-2-Enedioate
- Glutaconic acid, dimethyl ester
- NSC 30046
- dimethyl (2E)-pent-2-enedioate
- dimethyl (2Z)-pent-2-enedioate
- See more synonyms
- Dimethyl glutaconate
Dimethyl glutaconate is a reactive, tautomeric compound. It has shown to have a cross-linking effect on DNA, which may be useful in the treatment of tumors. Dimethyl glutaconate inhibits tumor growth by inhibiting the activity of topoisomerase II and III enzymes, which are involved in DNA replication. The inhibition of these enzymes leads to increased strand breakage and degradation of DNA.
As an anticancer agent, dimethyl glutaconate has been shown to inhibit the proliferation of various types of cancer cells including those found in breast, prostate and colon cancers. It also binds to purine derivatives such as adenine and guanine, which are essential for nucleotide synthesis. This binding prevents their incorporation into DNA or RNA molecules and inhibits nucleic acid production.
Chemical properties
Technical inquiry about: 3D-FAA16476 Dimethyl Glutaconate
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