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Product Information
- Glycine, N-(o-nitrophenyl)-
- NSC 12787
- [(2-Nitrophenyl)Amino]Acetic Acid
- glycine, N-(2-nitrophenyl)-
- N-(2-Nitrophenyl)glycine
- N-(2-Nitrophenyl)glycine
2-[(2-Nitrophenyl)amino]acetic acid (2NPA) is a selective antagonist with high affinity for the acetylcholine receptor. It has been shown to inhibit ionic currents in Xenopus oocytes expressing α-subunits of the nicotinic acetylcholine receptor. The compound binds to the site on the receptor that is normally occupied by acetylcholine and prevents it from binding to its normal binding site, thereby inhibiting functional activity. 2NPA was found to be a potent inhibitor of acetylcholine release in rat brain synaptosomes and inhibited acetylcholinesterase activity. 2NPA also inhibits cholinergic neurotransmission in the hippocampus, which may be due to its ability to block nicotinic receptors.
Chemical properties
Technical inquiry about: 3D-FAA42799 2-[(2-Nitrophenyl)amino]acetic acid
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