1-Bromopyrene

CAS: 1714-29-0

Ref. 3D-FB00284

Product Information

• Name: 1-Bromopyrene
• Brand: Biosynth

Description

1-Bromopyrene is a chemical that has been shown to be mutagenic and a carcinogen. It has been used extensively in research as a fluorescence probe for DNA, due to its ability to bind to dioxygen and other oxygen nucleophiles. 1-Bromopyrene reacts with the molecule pyrene, which emits light of different wavelengths depending on the type of reaction. The diazonium salt formed from this reaction is an effective electron donor in organic reactions and can be used as a chemical oxidant. 1-Bromopyrene also has significant photochemical properties.
1-Bromopyrene binds to DNA via hydrogen bonding between the bromine atom and the phosphate group of deoxyribose sugar in DNA, forming a covalent bond that alters the conformation of DNA by opening up the double helix structure. This causes oxidative damage to DNA by increasing reactive oxygen species (ROS) production and decreasing cellular antioxidant capacity.

Chemical properties

• Molecular weight: 281.15 g/mol
• Formula: C₁₆H₉Br
• Purity: Min. 95%
• Color/Form: White Powder
• InChI: InChI=1S/C16H9Br/c17-14-9-7-12-5-4-10-2-1-3-11-6-8-13(14)16(12)15(10)11/h1-9H
• InChI key: InChIKey=HYGLETVERPVXOS-UHFFFAOYSA-N
• SMILES: Brc1ccc2ccc3cccc4ccc1c2c34