5-Bromouracil

CAS: 51-20-7

Ref. 3D-FB04498

Product Information

• Name: 5-Bromouracil
• Synonyms: 2,4(1H,3H)-Pyrimidinedione, 5-bromo-, 2,4-Dihydroxy-5-Bromopyrimidine, 5-Bromo-2,4(1H,3H)-pyrimidinedione, 5-Bromo-2,4-dihydroxypyrimidine, 5-Bromo-2,4-pyrimidinedione, 5-Bromopyrimidine-2,4-diol, 5-Bromouracile, 5-Bromouracilo, 5-Bromuracil, 5-bromopyrimidine-2,4(1H,3H)-dione, Bromouracil, Nsc 19940, Uracil, 5-bromo-

Description

5-Bromouracil is a cytotoxic agent that inhibits the synthesis of DNA by inhibiting the enzyme thymine-5-bromo-2'-deoxyribonucleotide synthetase. It also has genotoxic effects on the organism, which can be observed in transfection experiments with human lymphocytes and polymerase chain reaction (PCR) experiments. 5-Bromouracil binds to the hydroxyl group of thymine and interacts with the nucleic acid bases, blocking the process of DNA synthesis. This drug is used to treat cancer in humans, but it is also toxic to eosinophils, which are white blood cells that produce chemicals such as peroxidases that help fight infections. The mechanism of action for 5-Bromouracil is not yet fully understood.

• Brand: Biosynth

Chemical properties

• Molecular weight: 190.98 g/mol
• Formula: C₄H₃BrN₂O₂
• Purity: Min. 95%
• Color/Form: Yellow Powder
• InChI: InChI=1S/C4H3BrN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
• InChI key: InChIKey=LQLQRFGHAALLLE-UHFFFAOYSA-N
• SMILES: O=c1[nH]cc(Br)c(=O)[nH]1