4-bromo-2,5-difluorobenzoic Acid

CAS: 28314-82-1

Ref. 3D-FB105797

Product Information

• Name: 4-bromo-2,5-difluorobenzoic Acid
• Synonyms: 4-Bromo-2,5-difluorobenzoic acid

Description

4-Bromo-2,5-difluorobenzoic acid is a potent inhibitor of isoforms CYP2C9 and CYP2D6. It is an acidic drug with a pKa of 3.8, which makes it ionizable in biological fluids. 4-Bromo-2,5-difluorobenzoic acid inhibits the activity of CYP2C9 and CYP2D6 by binding to the pharmacophore region of these enzymes. 4-Bromo-2,5-difluorobenzoic acid also has an isosteric functionality that increases its selectivity for CYP2C9 and CYP2D6 over other cytochrome P450 isoforms. The functional groups on 4-bromo-2,5-difluorobenzoic acid are part of the inhibitor's nature that make it selective for these two cytochrome

• Brand: Biosynth

Chemical properties

• Molecular weight: 237 g/mol
• Formula: C₇H₃BrF₂O₂
• Purity: Min. 95%
• InChI: InChI=1S/C7H3BrF2O2/c8-4-2-5(9)3(7(11)12)1-6(4)10/h1-2H,(H,11,12)
• InChI key: InChIKey=YWZSTHLOAZTDFJ-UHFFFAOYSA-N
• SMILES: O=C(O)c1cc(F)c(Br)cc1F