5-Bromoindole-2-carboxylic acid ethyl ester

CAS: 16732-70-0

Ref. 3D-FB12536

Product Information

• Name: 5-Bromoindole-2-carboxylic acid ethyl ester
• Synonyms: 2-(Ethoxycarbonyl)-5-Bromo-Indole, 1H-Indole-2-Carboxylic Acid, 5-Bromo-, Ethyl Ester, 5-Bromoindole-2-Carboxylic Acid Ethyl Ester, 5-Bromo-1H-Indole-2-Carboxylic Acid Ethyl Ester, 5-Bromo-2-Carbethoxyindole, Ethyl 5-Bromoindole-2-Carboxylate, Ethyl 5-Bromo-1H-Indole-2-Carboxylate
• CAS: 16732-70-0

Description

5-Bromoindole-2-carboxylic acid ethyl ester (5-BIEC) is a carboxamide antibiotic that inhibits the growth of gram-negative bacteria, including pneumoniae. 5-BIEC has been shown to have an inhibitory concentration (IC50) of 0.9 μM against Escherichia coli and other gram negative bacteria. It also has anti-proliferative effects on cancer cells, which may be due to its ability to inhibit DNA replication by binding to the beta subunit of DNA gyrase. 5-BIEC is currently being studied as a potential anticancer drug for the treatment of breast cancer, colon cancer, and leukemia.

• Brand: Biosynth

Chemical properties

• Molecular weight: 268.11 g/mol
• Formula: C₁₁H₁₀BrNO₂
• Purity: Min. 98 Area-%
• Color/Form: Powder
• InChI: InChI=1S/C11H10BrNO2/c1-2-15-11(14)10-6-7-5-8(12)3-4-9(7)13-10/h3-6,13H,2H2,1H3
• InChI key: InChIKey=LWRLKENDQISGEU-UHFFFAOYSA-N
• SMILES: CCOC(=O)c1cc2cc(Br)ccc2[nH]1