5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine

CAS: 799842-07-2

Ref. 3D-FB148744

Product Information

• Name: 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine
• Synonyms: Methanesulfonamide, N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-, N-(4-(4-Fluorophenyl)-5-(bromomethyl)-6-isopropyl-pyrimidin-2-yl)-N-methyl-methanesulfonamide, N-[5-(Bromomethyl)-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methylmethanesulfonamide, N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide, N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide, N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methyl methane sulfonamide, Rosuvastatin Intermediates Z-8, Z-7 Br

Description

Rosuvastatin is a statin drug that inhibits the enzyme HMG-CoA reductase. It is used to lower levels of cholesterol and other lipids in the blood, which may help prevent heart disease or stroke. Rosuvastatin is soluble in water and has a high melting point. It can be prepared as an acid salt by adding hydrochloric acid or sodium hydroxide to rosuvastatin calcium, depending on the desired pH. The hydrochloric acid salt of rosuvastatin is insoluble in water and has a low melting point, while the sodium salt dissolves well in water and has a high melting point. Rosuvastatin can be synthesized from 5-(bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine reagent, which is available as an industrial chemical for large-scale use.

• Brand: Biosynth

Chemical properties

• Molecular weight: 416.31 g/mol
• Formula: C₁₆H₁₉BrFN₃O₂S
• Purity: Min. 95%
• InChI: InChI=1S/C16H19BrFN3O2S/c1-10(2)14-13(9-17)15(11-5-7-12(18)8-6-11)20-16(19-14)21(3)24(4,22)23/h5-8,10H,9H2,1-4H3
• InChI key: InChIKey=PHEVHIWIKJRWDB-UHFFFAOYSA-N
• SMILES: CC(C)c1nc(N(C)S(C)(=O)=O)nc(-c2ccc(F)cc2)c1CBr