Product Information
- Butanoic acid, 4-hydroxy-, 1,1-dimethylethyl ester
Tert-butyl 4-hydroxybutyrate is an organic compound that is the tert-butyl ester of 4-hydroxybutyric acid. It can be synthesized by a regioselective synthesis from 3-hydroxypropanoic acid and butyric acid. Tert-butyl 4-hydroxybutyrate can also be synthesized by tethering hydroxylamines to prodrug form of tert-butanol. Tert-Butyl 4-hydoxybutyrate is a prodrug form of the drug, Terbumost, which is an esterase inhibitor used to treat ulcerative colitis. This drug has been shown to selectively inhibit the activity of esterases in the gastrointestinal tract and thereby reduce inflammation by inhibiting prostaglandin synthesis. This inhibition occurs at low doses and has little effect on other enzymes such as cytochrome P450 or glutathione reductase.
Chemical properties
Technical inquiry about: 3D-FB157013 tert-Butyl 4-hydroxybutyrate
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