2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol

CAS: 6976-37-0

Ref. 3D-FB15824

Product Information

• Name: 2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol
• Synonyms: Bis-TrisBis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane, 1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-, 1,3-dihydroxy-N,N-bis(2-hydroxyethyl)-2-(hydroxymethyl)propan-2-aminium, 2,2-Bis(Hydroxymethyl)-2,2',2''-Nitriloethanol, 2,2-Bis(hydroxymethyl)-2,2?2-nitrilotriethanol, 2,2-Bis(hydroxymethyl)-2,2′,2′′-nitrilotriethanol, 2-[Bis(2-Hydroxyethyl)Amino]-2-(Hydroxymethyl)Propane-1,3-Diol, 2-[Bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-1,3-propanediol, Bis Tris Bis(2-hydroxyethyl)imino-tris(hydroxymethyl)methane, Bis Tris, Molecular Biology Grade Bis(2-hydroxyethyl)imino-tris(hydroxymethyl)methane, Molecular Biology Grade, Bis(2-Hydroxyethyl)Amino-Tris(Hydroxymethyl)Methane, Bis(2-Hydroxyethyl)Imino-Tris(Hydroxymethyl)Propane, Bis(2-Hydroxyethyl)Iminotris(Hydroxymethyl)Methane, Bis(2-hydroxyethyl)-imino-tris-(hydroxymethyl)-methane biological buffer, Bis(2-hydroxyethyl)-tris(hydroxymethyl)methane, Bis(2-hydroxyethyl)aminotris(hydroxymethyl)methane, Bis(Hydroxyethyl)Imino-Tris-(Hydroxymethyl)-Methane, Bis-TRIS, Bis-Tris Buffer, Bistris, NSC 119932, NSC 24868, NuPage Bis-Tris

Description

2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol (BNTE) is a nitrilotriacetic acid derivative that is used in biochemical and cell culture experiments. It is a potential biomarker for colorectal adenocarcinoma and can be used to analyze the conformational properties of proteins. BNTE has been shown to have a high chemical stability and can be used as an alternative to sodium citrate in sample preparation. BNTE reacts with nucleophiles such as hydroxyl groups, which are present in proteins or peptides, to form stable tertiary amine intermediates. These intermediates are then reacted with electrophiles such as hydrogen peroxide in the presence of enzymes such as horseradish peroxidase. This reaction mechanism leads to the formation of a mass spectrum characteristic of group P2 atp levels that can be detected by plasma mass spectrometry.

• Brand: Biosynth

Chemical properties

• Molecular weight: 209.24 g/mol
• Formula: C₈H₁₉NO₅
• Purity: Min. 98%
• Color/Form: Powder
• InChI: InChI=1S/C8H19NO5/c10-3-1-9(2-4-11)8(5-12,6-13)7-14/h10-14H,1-7H2
• InChI key: InChIKey=OWMVSZAMULFTJU-UHFFFAOYSA-N
• SMILES: OCCN(CCO)C(CO)(CO)CO