Bis(4-methylphenyl) sulfone

CAS: 599-66-6

Ref. 3D-FB159532

Product Information

• Name: Bis(4-methylphenyl) sulfone
• Synonyms: Bis(p-tolyl) sulfoneDi-p-tolyl sulfonep,p'-Ditolyl sulfoneNSC 208
• Brand: Biosynth
• Description: Bis(4-methylphenyl) sulfone is an industrial chemical used in the manufacture of other chemicals. It is a sulfone that contains a hydroxyl group and a methylating agent. The reaction solution must be anhydrous and contain sodium carbonate, chloride, and methylating agent. The product can be synthesized by the Suzuki coupling reaction between an alkyl halide and an aryl boronic acid. This process requires activation energies of about 40-45 kcal/mol to drive the reaction forward. The hydrochloric acid reacts with the hydroxyl group on the sulfone to form a chlorosulfonic acid intermediate, which reacts with methylene chloride to produce bis(4-methylphenyl) sulfone. The carbonyl group on this intermediate is activated by adding methoxy groups, which are then replaced by chlorine atoms in order to form bis(4-chlorophenyl) sulfone.

Chemical properties

• Molecular weight: 246.33 g/mol
• Formula: C₁₄H₁₄O₂S
• Purity: Min. 95%
• InChI: InChI=1S/C14H14O2S/c1-11-3-7-13(8-4-11)17(15,16)14-9-5-12(2)6-10-14/h3-10H,1-2H3
• InChI key: InChIKey=WEAYCYAIVOIUMG-UHFFFAOYSA-N
• SMILES: Cc1ccc(S(=O)(=O)c2ccc(C)cc2)cc1