(R)-(-)-Mevalonolactone
CAS: 19115-49-2
Ref. 3D-FB162521
| 25mg | 1,044.00 € | ||
| 50mg | 1,449.00 € | ||
| 100mg | 2,087.00 € | ||
| 250mg | 3,768.00 € | ||
| 500mg | 5,794.00 € |
Product Information
- L-Mevalonolactone
- D-Mevalonic Acid Lactone
- D-Mevalonolactone
- (R)-(-)-3-Hydroxy-3-Methyl-5-Pentanolide
- (R)-Tetrahydro-4-Hydroxy-4-Methyl-2-Pyrone
- (R)-3-Hydroxy-3-methyl-δ-valerolactone, (R)-Mevalolactone, D-Mevalonic acid lactone
- 4-bromo-N'-hydroxybenzenecarboximidamide
- (4R)-4-hydroxy-4-methyltetrahydro-2H-pyran-2-one
Mevalonolactone is a sesquiterpene lactone that is found in plants such as the Madagascar periwinkle. It has been shown to have immunosuppressive and anti-inflammatory properties. Mevalonolactone has been used as a model system for the study of mevalonic acid, which is an intermediate in the synthesis of cholesterol. Mevalonolactone inhibits mevalonic acid-dependent enzymes, such as 3-hydroxy-3-methylglutaryl coenzyme A reductase and squalene synthase, which may lead to decreased production of cholesterol. This drug also inhibits mitochondrial functions, including ATP production and mitochondrial membrane potential. Mevalonolactone has been shown to have immunosuppressive effects on human serum by inhibiting cytokine release from activated T cells. It also reduces hepatic lipid levels in experimental models.
Chemical properties
Technical inquiry about: 3D-FB162521 (R)-(-)-Mevalonolactone
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