4-Benzyloxygramine

Ref. 3D-FB18512

Product Information

• Name: 4-Benzyloxygramine
• Synonyms: N,N-Dimethyl-4-(phenylmethoxy)-1H-indole-3-methanamine
• Brand: Biosynth
• Description: 4-Benzyloxygramine is an alkaloid that is a benzyl derivative of the indole nucleus. It has been shown to be an antagonist of lithium, calcium and potassium channels. The synthesis of 4-benzyloxyindole from 2-methyl-3-nitrophenol was achieved through a convergent approach. The debenzylated product was hydrolyzed with sodium hydroxide in water, followed by decarboxylation with aluminium chloride to form the desired product. 4-Benzyloxygramine reacts with benzaldehyde in the presence of potassium hydroxide to form 4-benzyloxyindole. This reaction involves an elimination of hydrogen bromide and formation of a double bond between carbon atoms 3 and 4 on the indole ring.

Chemical properties

• Molecular weight: 280.36 g/mol
• Formula: C₁₈H₂₀N₂O
• Purity: Min. 95%
• InChI: InChI=1S/C18H20N2O/c1-20(2)12-15-11-19-16-9-6-10-17(18(15)16)21-13-14-7-4-3-5-8-14/h3-11,19H,12-13H2,1-2H3
• InChI key: InChIKey=RRKLFSJBPYZCJV-UHFFFAOYSA-N
• SMILES: CN(C)Cc1c[nH]c2cccc(OCc3ccccc3)c12