Product Information
Name:Bis(4-cyanophenyl)methanol
Synonyms:
- 4,4'-(Hydroxymethylene)bisbenzonitrileBis(p-cyanophenyl)methanolCGP 44645
Brand:Biosynth
Description:Bis(4-cyanophenyl)methanol (BPM) is a toxic substance that is metabolized by the liver to 4-cyanophenol (4CP). BPM is used in clinical pharmacology as a marker for hepatic uptake and metabolism. BPM has been shown to induce cancer in animal studies, but it has not been shown to have any effect on human tissues. The effect of BPM on cancer development may be due to its ability to inhibit estrogen synthesis.
BPM also inhibits the enzyme aromatase, which converts androstenedione into estrone, which is then converted into estradiol.
Bis(4-cyanophenyl)methanol has also been shown to reduce the effects of letrozole, a drug commonly used in the treatment of breast cancer.
The concentration of BPM in plasma after oral ingestion varies with gender; women have higher concentrations than men at all time points after ingestion.
BPM also inhibits the enzyme aromatase, which converts androstenedione into estrone, which is then converted into estradiol.
Bis(4-cyanophenyl)methanol has also been shown to reduce the effects of letrozole, a drug commonly used in the treatment of breast cancer.
The concentration of BPM in plasma after oral ingestion varies with gender; women have higher concentrations than men at all time points after ingestion.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:234.25 g/mol
Formula:C15H10N2O
Purity:Min. 95%
InChI:InChI=1S/H3N/h1H3
InChI key:InChIKey=QGZKDVFQNNGYKY-UHFFFAOYSA-N
SMILES:N#Cc1ccc(C(O)c2ccc(C#N)cc2)cc1