N-t-Boc-valacyclovir
CAS: 502421-44-5
Ref. 3D-FB18986
| 1g | 300.00 € | ||
| 50mg | 59.00 € | ||
| 100mg | 88.00 € | ||
| 250mg | 131.00 € | ||
| 500mg | 179.00 € |
Product Information
- N-tert-Butoxycarbonyl-L-valine-2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester
- (S)-2-((2-Imino-6-oxo-2,3-dihydro-1H-purin-9(6H)-yl)methoxy)ethyl 2-((tert-butoxycarbonyl)amino)-3-methylbutanoate
- 2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl N-(tert-butoxycarbonyl)-L-valinate
- <span class="text-smallcaps">L</span>-Valine, N-[(1,1-dimethylethoxy)carbonyl]-, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester
- L-valine, N-[(1,1-dimethylethoxy)carbonyl]-, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester
- N-[(1,1-Dimethylethoxy)carbonyl]-<span class="text-smallcaps">L</span>-valine 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester
Valacyclovir is a prodrug that is hydrolyzed to acyclovir in the body. Valacyclovir is an ester of valine and cyclovir. The synthesis starts with the coupling of N-t-Boc-valine to 2,4-dichlorobenzyl alcohol. The product is then subjected to hydrolysis with hydrochloric acid in refluxing isopropanol, which yields N-t-Boc-valacyclovir. Hydrolysis of this compound under basic conditions gives the desired acyclovir. Acetylation of the hydroxyl group on the side chain of valine forms a methyl ester, which can be cleaved using an acidic solution (e.g., HCl) to give valacyclovir.
Chemical properties
Technical inquiry about: 3D-FB18986 N-t-Boc-valacyclovir
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