7-Bromo-2,3-dioxoindoline

CAS: 20780-74-9

Ref. 3D-FB35949

Product Information

• Name: 7-Bromo-2,3-dioxoindoline
• Synonyms: 1H-Indole-2,3-dione, 7-bromo-, 7-Bromoindole-1H-2,3-dione, 7-Bromoindole-2,3-dione, 7-Bromoindoline-2,3-Dione, 7-bromo-1H-indole-2,3-dione, Indole-2,3-dione, 7-bromo-, Isatin, 7-bromo-, 7-Bromoisatin

Description

7-Bromo-2,3-dioxoindoline is a synthetic compound with a vibrational frequency of 249.2 cm−1. It is an inhibitor of the enzyme synthetase and has been shown to have an inhibitory effect on cancer cell viability in vitro. 7-Bromo-2,3-dioxoindoline inhibits the production of cancerous cells by interfering with their ability to synthesize DNA, which is necessary for cell division. This inhibition may be due to its ability to form intermolecular hydrogen bonding interactions with the amine group on the enzyme synthetase. 7-Bromo-2,3-dioxoindoline has also been shown to block the synthesis of 5-chloroisatin, one of its reaction products. The bioassay was carried out by measuring the amount of granulosa cells that were able to produce estrogen after treatment with this compound.

• Brand: Biosynth

Chemical properties

• Molecular weight: 226.03 g/mol
• Formula: C₈H₄BrNO₂
• Purity: Min. 98 Area-%
• Color/Form: Powder
• InChI: InChI=1S/C8H4BrNO2/c9-5-3-1-2-4-6(5)10-8(12)7(4)11/h1-3H,(H,10,11,12)
• InChI key: InChIKey=OCVKSIWBTJCXPV-UHFFFAOYSA-N
• SMILES: O=C1Nc2c(Br)cccc2C1=O