3-Bromo-4-methylbenzoic acid

CAS: 7697-26-9

Ref. 3D-FB45071

Product Information

• Name: 3-Bromo-4-methylbenzoic acid
• Synonyms: 3-Bromo-4-Methylbenzoate, 3-Bromo-4-Methylbenzoicacid, 3-Bromo-4-methylbenzenecarboxylic acid, 3-Bromo-p-toluic acid, 3-Bromo-p-toluic acid (COOH=1), 4-Methyl -3-Bromobenzoic acid, Benzoic acid, 3-bromo-4-methyl-, NSC 243715, p-Toluic acid, 3-bromo-

Description

3-Bromo-4-methylbenzoic acid is a labile chemical compound that is used in the synthesis of retinoic acid, an analog of vitamin A. 3-Bromo-4-methylbenzoic acid can be synthesized by a two step process involving the boronic ester and biphenyl. The biphenyl is first treated with phosphorus pentachloride to produce a phenoxyacetate which reacts with 3-bromo-4-methylbenzoyl chloride in the presence of base to produce 3-bromo-4-methylbenzoic acid. This conversion can also be done via a solid phase synthesis where the biphenyl is anchored on silica gel and reacted with 3-bromo-4 methylbenzoyl chloride. The boronic esters are then cleaved from the solid support by treatment with sodium hydroxide under reflux conditions.
3 - Bromo -

• Brand: Biosynth

Chemical properties

• Molecular weight: 215.04 g/mol
• Formula: C₈H₇BrO₂
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C8H7BrO2/c1-5-2-3-6(8(10)11)4-7(5)9/h2-4H,1H3,(H,10,11)
• InChI key: InChIKey=ZFJOMUKPDWNRFI-UHFFFAOYSA-N
• SMILES: Cc1ccc(C(=O)O)cc1Br