Bedaquiline

CAS: 843663-66-1

Ref. 3D-FB46540

Product Information

• Name: Bedaquiline
• Synonyms: TMC207 (1R,2S)-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol
• Brand: Biosynth
• Description: Bedaquiline is a drug that inhibits the synthesis of mycobacterial RNA by binding to the ribosomal subunit. It is used to treat tuberculosis and multidrug-resistant tuberculosis. Bedaquiline has been shown to be bactericidal against wild-type strains of Mycobacterium tuberculosis and Mycobacterium avium complex, but not against multidrug-resistant strains of these bacteria. Bedaquiline also interacts with other drugs that inhibit the cytochrome P450 system, such as cycloserine or rifampin. Bedaquiline is active against MDR-TB but not against extensively drug resistant TB (XDR-TB).

Chemical properties

• Molecular weight: 555.5 g/mol
• Formula: C₃₂H₃₁BrN₂O₂
• Purity: Min. 95%
• Color/Form: White Powder