Product Information
- (1E)-butanal oxime
- (1Z)-butanal oxime
- Butanal oxime
- Butanaldoxime
- Butylaldoxime
- Butyraldehyde oxime
- N-hydroxybutan-1-imine
- NSC 1487
- n-Butylaldoxime
- n-Butyraldoxime
- See more synonyms
Butyraldoxime is a chemical that is used in the treatment of skin cancer. It has been shown to inhibit the growth of cultured human cells, including melanoma cells and leukemia cells. In vitro tests have shown that butyraldoxime inhibits sodium citrate-induced changes in cell morphology, an increase in cellular protein content and DNA synthesis, and an increase in tumor size. The mechanism of action for butyraldoxime is thought to be similar to that of the oxime inhibitor drugs. Oximes react with nitrite ion to form a reactive intermediate called nitrous acid, which reacts with caproic acid to form a nitric oxide radical. Nitric oxide radicals are then able to react with free methyl ethyl groups on the surface of cells and produce reactive oxygen species (ROS). ROS can cause damage to cell membranes, proteins and DNA within the cell. This damage may lead to cell death or inhibition of cellular function.
Chemical properties
Technical inquiry about: 3D-FB69970 Butyraldoxime
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