6-Chloro-3-aminopyridine-2-carboxamide

CAS: 175358-01-7

Ref. 3D-FC07007

Product Information

• Name: 6-Chloro-3-aminopyridine-2-carboxamide
• Synonyms: 3-Amino-6-Chloropicolinamide, 3-Amino-6-Chloropyridine-2-Carboxamide

Description

6-Chloro-3-aminopyridine-2-carboxamide is a small molecule that inhibits tumor growth in human prostate cancer cells. It binds to a pharmacophore, which is a three dimensional arrangement of atoms that is responsible for the biological activity of the drug. This compound has been shown to inhibit tumor cell proliferation and induce apoptosis. 6-Chloro-3-aminopyridine-2-carboxamide also inhibits the oncogenic signaling pathways, including the PI3K/Akt and MAPK pathways, leading to antiproliferative activity in cancer cell lines. 6-Chloro-3-aminopyridine-2-carboxamide also inhibits phosphorylation of Akt and Erk1/2, which are downstream targets of PI3K/Akt pathway activation. The compound was found to have no significant effects on noncancerous cells or normal prostate tissue.

• Brand: Biosynth

Chemical properties

• Molecular weight: 171.58 g/mol
• Formula: C₆H₆ClN₃O
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C6H6ClN3O/c7-4-2-1-3(8)5(10-4)6(9)11/h1-2H,8H2,(H2,9,11)
• InChI key: InChIKey=ZGGQDDSXBIALBC-UHFFFAOYSA-N
• SMILES: NC(=O)c1nc(Cl)ccc1N