6-Chloro-9-(tetrahydro-2H-pyran-2-yl)purine

CAS: 7306-68-5

Ref. 3D-FC08313

Product Information

• Name: 6-Chloro-9-(tetrahydro-2H-pyran-2-yl)purine
• Synonyms: 6-Chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine, 6-Chloro-9-(tetrahydropyran-2-yl)-9H-purine, 6-Chloro-9-(tetrahydropyran-2-yl)purine, 6-Chloropurine-THP, 9-(Tetrahydropyran-2-yl)-6-chloropurine, 9H-Purine, 6-chloro-9-(tetrahydro-2H-pyran-2-yl)-, 9H-Purine, 6-chloro-9-(tetrahydropyran-2-yl)-, NSC 33187, 6-chloro-9-(tetrahydro-2-pyranyl)purine, 6-Chloro-9-(tetrahydro-2-pyranyl)-purine

Description

6-Chloro-9-(tetrahydro-2H-pyran-2-yl)purine is a nucleoside analog that is used to treat various types of cancer. It is a c-h bond regiospecific nucleophile that forms the 6-chloro 9-(tetrahydro-2H-pyran-2-yl)purine intermediate. The chloride ion acts as a nucleophile in the first step of this process, which results in the formation of an organocuprate and glyoxylate. 6CPP binds to DNA and inhibits RNA synthesis, leading to cell death by apoptosis or necrosis. This drug has been shown to be effective for treating human cell lines. 6CPP is also known for its antitumor effects, which may be due to its ability to inhibit phosphonates and cross-coupling reactions.

• Brand: Biosynth

Chemical properties

• Molecular weight: 238.67 g/mol
• Formula: C₁₀H₁₁ClN₄O
• Purity: Min. 95%
• Color/Form: Solid
• InChI: InChI=1S/C10H11ClN4O/c11-9-8-10(13-5-12-9)15(6-14-8)7-3-1-2-4-16-7/h5-7H,1-4H2
• InChI key: InChIKey=QSTASPNCKDPSAH-UHFFFAOYSA-N
• SMILES: Clc1ncnc2c1ncn2C1CCCCO1