Product Information
- 6-Chloro-4-(2-Cyclopropylethynyl)-4-(Trifluoromethyl)-1H-3,1-benzoxazin-2-One
L 741211 is a hydrogen bond analog of the immunosuppressive drug FK506 (tacrolimus). It has been shown to have potent anti-HIV effects and is being investigated for use as an antiretroviral agent. L 741211 binds in a similar manner to FK506, but also has the ability to bind to human immunodeficiency virus (HIV) RNA. The binding of L 741211 with HIV RNA prevents the formation of new viruses by inhibiting reverse transcription and dsDNA synthesis. The molecule has been shown to be effective in preventing infection by HIV in animal models. The L 741211 molecule can exist in two tautomeric forms, which are due to resonance stabilization of the keto form. This keto form is more stable than the enol form, however both are active against HIV replication.
Chemical properties
Technical inquiry about: 3D-FC100188 L 741211
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