Product Information
- 4-Quinolyl(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol(5-Ethenyl-1-azabicyclo[2.2.2]oct-2-yl)(quinolin-4-yl)methanol
- (3alpha,9R)-cinchonan-9-ol
- (3alpha,9S)-cinchonan-9-ol
- (4beta,9S)-cinchonan-1-ium-9-ol
- (8R,9S)-Cinchonine
- (8alpha,9S)-cinchonan-9-ol
- (9R)-cinchonan-9-ol
- (9S)-9-hydroxycinchonan-1-ium
- (9S)-cinchonan-9-ol
- Alpha-(5-Vinyl-2-Quinuclidinyl)-4-Quinolinemethanol
- See more synonyms
- Cinchonan-9-Ol
- Cinchonan-9-ol, (9S)-
- Cinchonin
- Cinconina
- Nsc 6176
- d-Cinchonine
Cinchonine is a natural compound that has been found to have anti-cancer properties. It has shown to inhibit the growth of xenograft tumors in mice, which may be due to its ability to inhibit P-glycoprotein (P-gp). Cinchonine is metabolized by CYP2D6 and CYP3A4, with tiglic acid being the main metabolite. Cinchonine also has pro-apoptotic effects on HL60 cells and group P2 bowel disease. It has a structural analysis that includes an acetyl group at position 3 and methyl groups at positions 2 and 4. The reaction solution for cinchonine is shown below: Cinchonine can be synthesized from two molecules of pyridine via a condensation reaction with tiglic acid to form the intermediate nitrile followed by hydrolysis of the nitrile group with sodium hydroxide.
Chemical properties
Technical inquiry about: 3D-FC11047 Cinchonine
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