Calpain Inhibitor VI 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde

CAS: 190274-53-4

Ref. 3D-FC111099

Product Information

• Name: Calpain Inhibitor VI 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde
• Synonyms: SJA6017, 4-Fluoro-benzenesulfonyl-Val-L-leucinal
• Brand: Biosynth
• Description: Calpain inhibitor VI is a potent inhibitor of calpains. It blocks the enzymes that induce neuronal death and cell death, which induces apoptosis. Calpain inhibitor VI has been shown to have antiviral potency, inhibitory activity against activated T cells and inhibitory activity against inflammatory diseases, autoimmune diseases and cancer in vitro. This drug also inhibits the production of proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α), IL-1β, IL-6 and IL-12 by macrophages. Calpain inhibitor VI binds to cysteine residues on calpains with a binding constant of 1 nM. It has been shown to inhibit caspase-independent cell death induced by hydrogen peroxide in primary cells and can prevent primary cells from being dehydrated.

Chemical properties

• Molecular weight: 372.46 g/mol
• Formula: C₁₇H₂₅FN₂O₄S
• Purity: Min. 95%