3D-FC153743 - 2-chloro-4-methoxybenzaldehyde

4-[(2-Chloro-1,3-thiazol-5-yl)methoxy]-3-methoxybenzaldehyde

4-[(2-Chloro-6-fluorobenzyl)oxy]-3-methoxybenzaldehyde

Versatile small molecule scaffold

2-Chloro-4-hydroxy-3-methoxybenzaldehyde (4CMB) is a benzaldehyde derivative with a syringic acid moiety. It has been shown to have antiallergic effects and can be used in the treatment of asthma and other allergic diseases. The demethylation of 4CMB produces 2,4,6-trimethoxybenzaldehyde (2,4,6TMB). This compound has been shown to have antimicrobial properties against methicillin resistant Staphylococcus aureus and Clostridium perfringens. 4CMB also has the ability to inhibit the proliferation of cancer cells in vitro by binding to DNA sequences that are involved in transcriptional regulation.

2-Chloro-4-hydroxy-5-methoxybenzaldehyde is an organic compound with the chemical formula C6H3ClO2. It is a member of the aldehyde family and has an oxidation potential of 1.8 V. The compound is soluble in water and alcohols but insoluble in ethers. 2-Chloro-4-hydroxy-5-methoxybenzaldehyde can be prepared by reduction of o,p′-dichlorobenzaldehyde with lithium aluminum hydride or sodium borohydride at 0°C. The compound can also be synthesized by heating o,p′-dichlorobenzaldehyde to 170°C in the presence of sulfuric acid and then treating the reaction product with potassium hydroxide at room temperature to yield 2,4,5,6,-tetrachloroquinone which then undergoes demethylation to form 2,4,

Versatile small molecule scaffold

Versatile small molecule scaffold