Carmustine

CAS: 154-93-8

Ref. 3D-FC19817

Product Information

• Name: Carmustine
• Synonyms: N,N'-Bis(2-chloroethyl)-N-nitrosourea, NSC-409962, Becenun, 1,3-Bis(2-Chloroethyl)-1-Nitroso-Urea, 1,3-Bis(2-chlorethyl)-1-nitrosourea, 1,3-Bis(2-chloroethyl)-1-nitrosourea, 1,3-Bis(2-chloroethyl)nitrosourea, 1,3-Bis(β-chloroethyl)-1-nitrosourea, Bcnu, Becenum, BiCNU, Carmubris, Carmustin, Carmustina, Dti 015, Fda 0345, Gliadel, Gliadel Wafer, Nitrumon, Nsc 409962, Sk 27702, Sri 1720, Urea, 1,3-bis(2-chloroethyl)-1-nitroso-, Urea, N,N'-bis(2-chloroethyl)-N'-nitroso-
• CAS: 154-93-8

Description

Carmustine is a DNA alkylating agent which also cross-links DNA. As a result Carmustine disrupts the function of DNA, resulting in the arrest the cell cycle and apoptosis. Consequently these properties of Carmustine, in addition to its ability to easily transmit through the blood-brain barrier, mean it can be used as a cancer treatment, treating cancers such as, breast, ovarian and pancreatic as well as lymphomas and leukemias. Furthermore Carmustine can contribute to cytotoxic effects through its ability to carbamoylate DNA repair enzymes and proteins.

• Brand: Biosynth

Chemical properties

• Molecular weight: 214.05 g/mol
• Formula: C₅H₉Cl₂N₃O₂
• Purity: Min. 85%
• Color/Form: Powder
• InChI: InChI=1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)
• InChI key: InChIKey=DLGOEMSEDOSKAD-UHFFFAOYSA-N
• SMILES: O=NN(CCCl)C(=O)NCCCl