(R)-(+)-Carvedilol

CAS: 95093-99-5

Ref. 3D-FC19827

Product Information

• Name: (R)-(+)-Carvedilol
• Synonyms: (+)-1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol(+)-Carvedilol(R)-Carvedilol
• CAS: 95093-99-5

Description

Carvedilol is a racemic mixture of the enantiomers (-) and (+) that are mirror images of each other. It is used in the treatment of congestive heart failure and ventricular dysfunction by acting as a vasodilator and reducing cardiac workload. Carvedilol has been shown to reduce blood pressure, decrease plasma levels of α1-acid glycoprotein, increase the excretion of teicoplanin, and inhibit cytosolic calcium release. Carvedilol also binds stereoselectively to the ryanodine receptor in rat hearts and inhibits on-line cytosolic calcium release. The (+) enantiomer has been shown to have greater potency than (-) at binding to the ryanodine receptor.

• Brand: Biosynth

Chemical properties

• Molecular weight: 406.47 g/mol
• Formula: C₂₄H₂₆N₂O₄
• Purity: Min. 95%
• Color/Form: White Powder
• InChI: InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3/t17-/m1/s1
• InChI key: InChIKey=OGHNVEJMJSYVRP-QGZVFWFLSA-N
• SMILES: COc1ccccc1OCCNC[C@@H](O)COc1cccc2[nH]c3ccccc3c12