Chrysophanic acid

CAS: 481-74-3

Ref. 3D-FC20424

Product Information

• Name: Chrysophanic acid
• Synonyms: 1,8-Dihydroxy-3-methyl-9,10-anthracenedione1,8-Dihydroxy-3-methylanthraquinone3-Methylchrysazin, 1,8-Dihidroxi-3-Metilantraquinona, 1,8-Dihydroxy-3-Methylanthracene-9,10-Dione, 1,8-Dihydroxy-3-Methylanthraquinone, 1,8-Dihydroxy-3-methyl-9,10-anthracenedione, 1,8-Dihydroxy-3-methyl-9,10-anthraquinone, 1,8-Dihydroxy-3-methyl-anthraquinone, 1,8-Dihydroxy-3-methylanthrachinon, 2-Methyl-4,5-dihydroxyanthraquinone, 3-Methyl-1,8-dihydroxyanthraquinone, 3-Methylchrysazin, 4,5-Dihydroxy-2-methylanthraquinone, 9,10-Anthracenedione, 1,8-dihydroxy-3-methyl-, Anthraquinone, 1,8-dihydroxy-3-methyl-, Nsc 37132, Nsc 646567, Turkey Rhubarb, C.I. 75400

Description

Chrysophanic acid is a natural compound that has been shown to inhibit the activity of Cox-2 and COX-1, two enzymes involved in the inflammatory response. Chrysophanic acid also inhibits the production of prostaglandins, which are involved in pain and inflammation. The cytotoxicity of chrysophanic acid has been evaluated by testing its effect on HL-60 cells. This compound induces apoptosis in HL-60 cells by stimulating a calcium influx into the cytosol and changes in signal pathways that lead to mitochondrial membrane potential loss. Chrysophanic acid has been shown to be toxic to squamous carcinoma cell lines but not to normal human keratinocytes. It also inhibits the growth of cancerous cells at low doses but does not affect healthy cells.

• Brand: Biosynth

Chemical properties

• Molecular weight: 254.24 g/mol
• Formula: C₁₅H₁₀O₄
• Purity: Min. 95 Area-%
• Color/Form: Powder
• InChI: InChI=1S/C15H10O4/c1-7-5-9-13(11(17)6-7)15(19)12-8(14(9)18)3-2-4-10(12)16/h2-6,16-17H,1H3
• InChI key: InChIKey=LQGUBLBATBMXHT-UHFFFAOYSA-N
• SMILES: Cc1cc(O)c2c(c1)C(=O)c1cccc(O)c1C2=O