Product Information
Name:Efavirenz
Synonyms:
- (4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
Brand:Biosynth
Description:Efavirenz is a non-nucleoside-based reverse transcriptase inhibitor (NNRTI) of the reverse transcriptase of HIV-1. It inhibits the viral enzyme reverse transcriptase by binding to its active site. In certain cell culture assays, efavirenz showed great efficiency when inhibiting wild-type HIV-1 replication with values of inhibition constant Ki between 2.97 to 17.60 mM in single mutation enzymes and 26.05 to 56.50 nM in double mutation. In the treatment of HIV, efavirenz has been studied in combination with emtricitabine and tenofovir disoproxil fumarate for ease of administration in some clinical studies. Recent in vitro cell studies indicated efavirenz is a potential treatment for pancreatic, prostate and triple-negative breast cancers due to its cytotoxicity against cancer cells, with an EC50 of 31.5 μM.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:315.68 g/mol
Formula:C14H9ClF3NO2
Purity:Min. 95%
Color/Form:Powder
SMILES:O=C1Nc2ccc(Cl)cc2C(C#CC2CC2)(C(F)(F)F)O1
Technical inquiry about: Efavirenz
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