Coelenterazine F

CAS: 123437-16-1

Ref. 3D-FC30724

Product Information

• Name: Coelenterazine F
• Synonyms: Coelenterazine-fluoride8-Benzyl-2-(4-fluorobenzyl)-6-(4-hydroxyphenyl)imidazo[1,2-α]pyrazin-3(7H)-one, 2-(P-Fluorobenzyl)-6-(P-Hydroxyphenyl)-8-Benzylimidazo[1,2-A]Pyrazin-3-(7H)-One, 2-(P-Fluorobenzyl)-6-(P-Hydroxyphenyl)-8-Benzylimidazo[1,2-A]Pyrazine-3-(7H)-One, Clz-F, Clzn-F, Coelenterazine-F, Synthetic, 8-benzyl-2-(4-fluorobenzyl)-6-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one

Description

Coelenterazine F is a light-emitting molecule that has been shown to emit light when it binds to cytosolic Ca2+. In addition, it can be used in the detection of Ca2+ changes. The molecular structure consists of two disulfide bonds and a reactive cysteine residue that can form covalent bonds with other molecules. This reaction releases energy in the form of light. Coelenterazine F has been shown to produce fluorescence resonance energy transfer (FRET) with luciferase, which is a reconstituted protein complex that emits light when oxidized by coelenterazine F. Coelenterazine F has also been shown to induce pro-inflammatory cytokines, such as IL-6 and TNF-α, which are involved in inflammatory response.

• Brand: Biosynth

Chemical properties

• Molecular weight: 425.45 g/mol
• Formula: C₂₆H₂₀FN₃O₂
• Purity: Min. 95 Area-%
• Color/Form: Orange Powder
• InChI: InChI=1S/C26H20FN3O2/c27-20-10-6-18(7-11-20)15-23-26(32)30-16-24(19-8-12-21(31)13-9-19)28-22(25(30)29-23)14-17-4-2-1-3-5-17/h1-13,16,31-32H,14-15H2
• InChI key: InChIKey=MEMQQZHHXCOKGG-UHFFFAOYSA-N
• SMILES: Oc1ccc(-c2cn3c(O)c(Cc4ccc(F)cc4)nc3c(Cc3ccccc3)n2)cc1