6-Chloroisatin
CAS: 6341-92-0
Ref. 3D-FC32700
| 25g | 136.00 € | ||
| 50g | 196.00 € | ||
| 100g | 352.00 € | ||
| 250g | 711.00 € | ||
| 500g | 1,148.00 € |
Product Information
- 6-Chloroindole-2,3-dione6-Chloro-2,3-indolinedione
- Buttpark 50\07-92
- 6-Chloro-1H-Indole-2,3-Dione
- 3-(5-{(E)-[1-(3-bromophenyl)-2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene]methyl}furan-2-yl)-4-methylbenzoic acid
6-Chloroisatin is a potent inhibitor of bacterial growth that binds to the 50S ribosomal subunit. It has been shown to have strong inhibitory activity against tuberculosis and sulphamethoxazole-resistant strains of Mycobacterium tuberculosis. 6-Chloroisatin inhibits bacterial growth by binding to the 50S ribosomal subunit, thereby preventing protein synthesis and cell division. The electron deficient form of 6-chloroisatin reacts with the electron rich sulphamethoxazole by displacement of chloride ion from the sulphonamide ring, forming a regiospecific product that inhibits bacterial respiration. This reaction system is inhibited by activated carbon, which may be a potential therapeutic strategy for patients with drug resistant tuberculosis.
Chemical properties
Technical inquiry about: 3D-FC32700 6-Chloroisatin
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