Carmofur

CAS: 61422-45-5

Ref. 3D-FC60423

Product Information

• Name: Carmofur
• Synonyms: 5-Fluoro-1-hexylcarbamoyluracil
• Brand: Biosynth
• Description: Carmofur is a fluorouracil derivative that interferes with nucleotide metabolism and consequently with synthesis of RNA and DNA, leading to cytotoxic and antineoplastic effects. Carmofur inhibits also other enzymes such as lysosomal acid ceramidase and the main protease from coronaviruses. For the SARS-CoV-2 main protease Mpro, carmofur was characterised as a covalent inhibitor with IC50 of 1.82 μM and EC50 of 24.30 μM.

Chemical properties

• Molecular weight: 257.26 g/mol
• Formula: C₁₁H₁₆FN₃O₃
• Purity: Min. 95%
• Color/Form: White Powder
• InChI: InChI=1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18)
• InChI key: InChIKey=AOCCBINRVIKJHY-UHFFFAOYSA-N
• SMILES: CCCCCCNC(=O)n1cc(F)c(=O)[nH]c1=O