Cefazolin impurity E

CAS: 29490-19-5

Ref. 3D-FC63655

Product Information

• Name: Cefazolin impurity E
• Synonyms: 1,3,4-Thiadiazole-2(3H)-thione, 5-methyl-, 2-Methyl-1,3,4-thiadiazol-5-thiol, 2-Methyl-1,3,4-thiadiazole-5-thiol, 2-Methyl-1,3,4-thiadiazoline-5-thione, 2-Methyl-5-Mercapto Thiadiazole(Mmtd), 2-Methyl-5-mercapto-1,3,4-thiadiazole, 2-Methyl-5-mercaptothiadiazole, 5-Mercapto-2-methyl-1,3,4-thiadiazole, 5-Methyl-1,3,4-thiadiazol-2-thiol, 5-Methyl-1,3,4-thiadiazole-2-thiol, 5-Methyl-1,3,4-thiadiazole-2-thione, 5-Methyl-1,3,4-thiadiazole-5-thiol, 5-Methyl-1,3,4-thiadiazolyl-2-thiol, 5-Methyl-1,3,4-thiazole-2-thione, 5-Methyl-2-mercapto-1,3,4-thiadiazole, 5-Methyl-2-sulfanyl-1,3,4-thiadiazole, 5-Methyl-3H-1,3,4-thiadiazole-2-thione, 5-methyl-1,3,4-thiadiazole-2(3H)-thione, Mmtd, Thiadiazole, Δ²-1,3,4-Thiadiazoline-5-thione, 2-methyl-, Δ2-1,3,4-Thiadiazoline-5-thione, 2-methyl-, 2-Mercapto-5-methyl-1,3,4-thiadiazole

Description

Cefazolin impurity E (CEF-E) is an impurity of the antibiotic cefazolin. It has been shown to have a redox potential and adsorption mechanism of -0.39 V and 0.14, respectively. CEF-E has been found in urine samples as a result of chemical interactions with nitrogen atoms in the urine. The binding constants for CEF-E are 1.7 x 10^10 M^(-1). The molecular weight of CEF-E is 289.2 g/mol and its nmr spectrum is characterized by peaks at 3.03 ppm and 4.41 ppm, which correspond to C-H protons in the methylene side chain and N-H protons in the pyridine ring, respectively. CEF-E also binds to human liver cells with an inhibitory effect on chloride ion transport, which may be due to its ability to chelate chloride ions with its chelate ring structure.

• Brand: Biosynth

Chemical properties

• Molecular weight: 132.21 g/mol
• Formula: C₃H₄N₂S₂
• Purity: Min. 95%