Product Information
- 3-(2-cyanophenyl)prop-2-enoic acid
- (2E)-3-(2-Cyanophenyl)acrylic acid
- 2-Propenoic acid, 3-(2-cyanophenyl)-, (2E)-
2-Cyanocinnamic acid is a fatty acid that has been shown to inhibit the synthesis of proteins. It binds to cytochrome c oxidase, inhibiting mitochondrial respiration and electron transport, leading to decreased ATP production. 2-Cyanocinnamic acid is not easily transported out of mitochondria, which leads to its accumulation in the mitochondrial matrix. This accumulation causes synergistic inhibition with glutamate, leading to a decrease in ATP production and an increase in intracellular levels of reactive oxygen species (ROS). The use of 2-cyanoacrylic acid as a mitochondrial transport inhibitor has been proposed for the treatment of obesity and diabetes.
2-Cyanocinnamic acid also inhibits fatty acid uptake by binding to the protein translocase at the outer membrane of cells. This binding prevents monomers from entering the cell, where they are broken down by beta oxidation and converted into acetyl-CoA, which can be used for energy production or stored as triglycer
Chemical properties
Technical inquiry about: 3D-FC66231 2-Cyanocinnamic acid
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