Product Information
- 6-Chloroquinoxaline
- Quinoxaline, 6-chloro-
7-Chloroquinoxaline is a nucleophilic compound that can be synthesized by reductive chlorination of 7-chloroquinoline. 7-Chloroquinoxaline has been shown to have anticancer activity in vitro, as well as the ability to inhibit the proliferation of human breast cancer cells (MCF-7) in culture. It also inhibits glyoxalase I and II, which are enzymes that catalyze the conversion of glyoxal to D-lactate and H2O2. This inhibition may be due to its ability to react with the C=N bond at carbon 2 of dimethylformamide (DMF), forming a covalent adduct with DMF and an anticancer agent such as methotrexate or 5-fluorouracil. The formation of this conjugate would result in a decrease in DMF concentration, leading to decreased production of H2O2 and increased levels of D-l
Chemical properties
Technical inquiry about: 3D-FC66699 7-Chloroquinoxaline
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