3-Carboxycinnamic acid

CAS: 25974-99-6

Ref. 3D-FC70003

Product Information

• Name: 3-Carboxycinnamic acid
• Brand: Biosynth
• Description: 3-Carboxycinnamic acid is a metabolite of cinnamic acid and belongs to the group of phenols. It is a potent inducer of apoptosis in human carcinoma cell lines, with potency comparable to all-trans retinoic acid. 3-Carboxycinnamic acid has been shown to induce apoptosis by increasing the expression of proapoptotic proteins such as Bax and decreasing the expression of antiapoptotic proteins such as Bcl-2. 3-Carboxycinnamic acid also interacts with other transcriptional regulators, including all-trans retinoic acid, which may explain its potent cytotoxic effects. This compound has been shown to inhibit cell cycle progression at G2/M phase by inhibiting DNA synthesis. In addition, 3-carboxycinnamic acid can increase protein synthesis in liver cells, but inhibits it in cardiac cells.

Chemical properties

• Molecular weight: 192.17 g/mol
• Formula: C₁₀H₈O₄
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C10H8O4/c11-9(12)5-4-7-2-1-3-8(6-7)10(13)14/h1-6H,(H,11,12)(H,13,14)/b5-4+
• InChI key: InChIKey=KLWPBEWWHJTYDC-SNAWJCMRSA-N
• SMILES: O=C(O)/C=C/c1cccc(C(=O)O)c1