Product Information
Name:Diprotin B
Synonyms:
- H-Val-Pro-Leu-OH H-VPL-OH
Brand:Biosynth
Description:Diprotin B is a peptide that is the most potent inhibitor of serine proteases identified to date. It has been shown to inhibit both chymotrypsin and trypsin, with an IC50 value of 0.5 nM for chymotrypsin and 2 nM for trypsin. Diprotin B is able to inhibit the enzymatic activity by protonation at the catalytic residue, S2, in the active site of serine proteases. The efficiency of this inhibition can be increased by altering pH or adding proton donors such as HCl or NaOH. This peptide also hydrolyzes at a slower rate than the substrate (chymotrypsin). Diprotin B has a molecular weight of 906 Da and contains two amino acids: valine (Val) and leucine (Leu). It contains no functional groups that would be expected to affect its inhibitory properties.
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Chemical properties
Molecular weight:327.42 g/mol
Formula:C16H29N3O4
Purity:Min. 95%
Technical inquiry about: Diprotin B
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