DABCYL-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS trifluoroacetate salt

CAS: 142988-22-5

Ref. 3D-FD110909

Product Information

• Name: DABCYL-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS trifluoroacetate salt
• Synonyms: 4-(4-Dimethylaminophenylazo)benzoyl-4-aminobutanoyl-isoleucyl-histidyl-prolyl-phenylalanyl-histidyl-leucyl-valyl-isoleucyl-histidyl-threonyl-5-((2-aminoethyl)amino)naphthalene-1-sulfonic acid, Dabcyl-GABA-ile-his-pro-phe-his-leu-val-ile-his-thr-edans, Dabgab-ipfit-edans, N-(4-((4-((4-(Dimethylamino)phenyl)azo)benzoyl)amino)-1-oxobutyl)-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucyl-L-valyl-L-isoleucyl-L-histidyl-N-(2-((5-sulfo-1-naphthalenyl)amino)ethyl)-L-threoninamide, L-Threoninamide, N-(4-((4-((4-(dimethylamino)phenyl)azo)benzoyl)amino)-1-oxobutyl)-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucyl-L-valyl-L-isoleucyl-L-histidyl-N-(2-((5-sulfo-1-naphthalenyl)amino)ethyl)-

Description

DABCYL-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr (DABCYL) is a fluorescent substrate that has been used to study the kinetics of peptide hydrolysis by proteases. It is an amino acid sequence that is present in angiotensinogen, which is a blood protein involved in regulating blood pressure. The DABCYL group on the terminal amino acid of the peptide provides a highly fluorescent molecule that can be excited at wavelengths longer than 400 nm. This fluorophore can also be used as a donor for fluorescence resonance energy transfer (FRET) with other fluorophores, such as EDANS, which has been shown to have high affinity for DABCYL. DABCYL can be used to measure enzyme activity or inhibition and has been found to be sensitive enough to detect changes due to dilutions at concentrations as low as 10 nM.

• Brand: Biosynth

Chemical properties

• Molecular weight: 1,798.12 g/mol
• Formula: C₉₀H₁₂₀N₂₂O₁₆S
• Purity: Min. 95%