Product Information
Name:Neflamapimod
Synonyms:
- 5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-B]pyridazine-6-one
Brand:Biosynth
Description:5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-B]pyridazine-6-one (NVP-BEZ235) is a molecule that inhibits the activity of the phosphoinositide 3 kinase (PI3K) pathway. This pathway regulates cell growth and survival by controlling cellular energy production and distribution. The PI3K pathway is active in a number of cancers, including colorectal cancer and acute myeloid leukemia. NVP-BEZ235 has been shown to be effective for treating bowel disease and inflammatory bowel disease in clinical trials. In addition, it is also an effective treatment for cancer with platinum based chemotherapy. The most common side effects are nausea, vomiting, diarrhea, constipation, anorexia, fatigue and headache.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:436.26 g/mol
Formula:C19H9Cl2F2N3OS
Purity:Min. 95%
InChI:InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H
InChI key:InChIKey=VEPKQEUBKLEPRA-UHFFFAOYSA-N
SMILES:O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl
Technical inquiry about: Neflamapimod
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