4'-Demethylepipodophyllotoxin

CAS: 6559-91-7

Ref. 3D-FD21027

Product Information

• Name: 4'-Demethylepipodophyllotoxin
• Synonyms: (5R,5aR,8aR,9S)-9-Hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• Brand: Biosynth
• Description: 4'-Demethylepipodophyllotoxin is a semisynthetic lignan, derived from the toxin podophyllotoxin, which is extracted from the roots and rhizomes of Podophyllum species, such as Podophyllum peltatum. The compound acts primarily as a topoisomerase II inhibitor. By binding to and stabilizing the enzyme-DNA complex, it prevents the re-ligation of DNA strands, which ultimately leads to breaks in the DNA and triggers apoptosis in rapidly dividing cancer cells.

Chemical properties

• Molecular weight: 400.38 g/mol
• Formula: C₂₁H₂₀O₈
• Color/Form: Powder